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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Biguanides
supplement:
Glucose
Research Papers that Mention the Interaction
“ Biguanide consistently lowered hepatic glucose output while not significantly affecting the removal of glucose from the circulation.”
“On balance, it is concluded that the acute hypoglycemic action of this biguanide is mediated primarily through a restriction in the supply of glucose from the liver to the circulation.”
The mechanism of the acute hypoglycemic action of phenformin (DBI).“Earlier … biguanideg and sulfonylurea'O''' … insulin response to glucose in obese, normal, and diabetic patients stimulated a series of studies designed to compare the acute actions of a biguanide, … a placebo upon the insulin-carbohydrate relationship in a group of obese adult-onset diabetics attending a city hospital clinic.”
“Our findings indicate that antitumor action of biguanides can be mediated by 4E-BP1 hyperactivation, which results in UPR inhibition and selective cell killing when glucose is withdrawn.”
“Suppression of intestinal glucose absorption by biguanide derivatives , demonstrated in the present study, could be explained by specific action of these compounds on the small intestine wall.”
“The benefits of this latter treatment are: 1) insulin substitution with insulin analogue responding especially quickly, thereby stopping the glycaemic level from falling; …, Glinides, [Novonorm, Starlix]); 3) agents which raise the sensibility to insulin (glitazones, [Avandia], biguanides); 4) molecules which interfere with the absorption of the glucose at … ( biguanides …).”
“These data provide evidence, therefore, that biguanides may directly influence the cellular utilization of glucose.”
“ Biguanides inhibited transport of D-glucose , D-galactose and 3-0-methyl-D-glucose but had no effect on the transport of D-fructose.”
Analysis of the inhibitory effect of biguanides on glucose absorption: Inhibition of active sugar transport“Metabolic flux and fluorescence-activated cell sorting analyses of tumor cells revealed that the biguanides strongly inhibited oxidative phosphorylation and activated compensative glycolysis in the presence of glucose , whereas both were strongly suppressed in the absence of glucose, resulting in cellular energy depletion and apoptosis.”
Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment“ Biguanides also increase peripheral uptake of glucose [7].”
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