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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Bezafibrate
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“To understand further the role of PE methylation, we determined the effect of bezafibrate , an inhibitor of PE methylation, on VLDL assembly within the microsomal lumen.”
Inhibition of phosphatidylcholine synthesis via the phosphatidylethanolamine methylation pathway impairs incorporation of bulk lipids into VLDL in cultured rat hepatocytes DOI 10.1194/jlr.M100354-JLR200“Furthermore, the methylation of PE derived from serine was also blocked by bezafibrate , as was the secretion of PC derived from either serine or ethanolamine.”
“We have shown that bezafibrate and clofibric acid, known hypolipidemic agents, are potent inhibitors of PE methylation (see accompanying paper by Nishimaki-Mogami et al. (1996) Biochim.”
“In contrast, CFB and BFB enhanced eicosatrienoic and mead acids in both fractions and arachidonic acid in phosphatidylethanolamine , whereas GFB had practically no effect.”
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