supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Bezafibrate
supplement:
Niacin
Research Papers that Mention the Interaction
“In patients with isolated low HDL cholesterol levels, bezafibrate increased this parameter by about 30%; adding nicotinic acid raised it further.”
Erratum to: Bezafibrate: an update of its pharmacology and use in the management of dyslipidaemia“It is concluded that low doses of nicotinic acid may result in significant changes in HDL cholesterol; when combined with bezafibrate significant alterations in total cholesterol, triglycerides and total/HDL cholesterol also result.”
“The results indicate that the combination of bezafibrate and niacin produces a significant hypolipidemic response, with major site(s) of action located presystemically.”
“… bezafibrate, … niacin , 40 mg/kg/day for 3 days (Models A and B) or for 18 h (Model C)] produced significantly greater lowering of total cholesterol … lipoprotein (HDL) cholesterol in comparison with intermittent oral administration of the same doses either given individually or in combination (Models A and B).”
Pharmacodynamic effects of bezafibrate and niacin combination: implications of the mode of administration.“ Bezafibrate was effective hypolipidemic agent in normal rats, but addition of nicotinic acid has certainly improved the effectiveness further which could be of clinical significance.”
“However, in their therapeutic effectiveness, bezafibrate reduced triglycerides (65.4%) and nicotinic acid , cholesterol (39.3%).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback