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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Betaine
drug:
Zalcitabine
Research Papers that Mention the Interaction
“ Betaine significantly prevented transcript silencing of Ufm1, Uba5 and UfSP1 where MDBs developed and also prevented the increased expression of FAT10 and LMP7 caused by DDC re-fed mice.”
“In this study, we further discovered that betaine , a methyl donor, fed together with DDC significantly prevents the increased expression of Ufmylation in drug-primed mice fed DDC.”
Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).“ Betaine also significantly prevented the decreased expression of BHMT, AHCY, MAT1a and GNMT and the increased expression of MTHFR, caused by DDC refeeding.”
“S-Adenosylhomocysteine (SAH) levels were reduced by DDC refeeding and this was prevented by betaine.”
Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms.
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