Possible Interaction: Betaine and Vitamin B 12

“ Vitamin B12 given in the evening either alone or together with betaine increased the TDGA excretion in the morning urine up to ten times.”

“… aine co … amin B12 bi osynthetic pathway, which was mainly reflected in the following three aspects: 1) the δ-aminolevulinic acid (ALA) synthase and porphobilinogen synthase that were responsible for …-stage key enzymes (Cobaltochelatase, and Cob(I)yrinic acid a,c-diamide adenosyltransferase) that were related to cobalt chelation of vitamin B12 molecule.”

“By further using a comparative metabolomics approach coupled … g/l) or not, it was found that betaine … vitamin B12 biosynthesis, such as δ-aminolevulinic acid (ALA, the first precursor of vitamin B12), glutamate (an … pathway), and methionine (directly participating in the methylation reaction involved in vitamin B12 biosynthetic pathway).”

“Results obtained from shake flask experiments showed that the feeding of carbon source (beet molasses or glucose) and methyl-group donor betaine or choline chloride) significantly influenced the pH and the biosynthesis of vitamin B12.”

“The results obtained in shake-flask experiments demonstrated that betaine could greatly stimulate vitamin B12 biosynthesis but had an inhibition to cell growth.”

“METHYL donors such as betaine and choline are known to stimulate production of vitamin B12 by certain microorganisms1.”