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Last Updated: 2 years ago

Possible Interaction: Betaine and S-Adenosylmethionine

supplement:

Betaine

Research Papers that Mention the Interaction

Betaine , a naturally occurring metabolite of choline, has been shown to raise S-adenosylmethionine ( SAM ) levels that may in turn play a role in decreasing hepatic steatosis.
American Journal of Gastroenterology  •  2001  |  View Paper
Concentrations of cystathionine, cysteine, betaine , choline, dimethylglycine, S-adenosylhomocysteine (SAH), S-adenosylmethionine ( SAM ), and holotranscobalamin were significantly higher in DS compared to the controls.
Molecular nutrition & food research  •  2012  |  View Paper
In all affected children, treatment with betaine (534+/-222 mg/kg/day) increased plasma S-adenosylmethionine , improved markers of tissue methyltransferase activity, and resulted in a threefold increase of calculated brain methionine uptake.
Molecular genetics and metabolism  •  2007  |  View Paper
This explains how SAMe and betaine prevented the cycle.
Experimental and molecular pathology  •  2011  |  View Paper
Betaine increased hepatic S-adenosyl-L-methionine by 28 fold in the knockouts and by 24-fold in wild type.
Hepatology  •  2004  |  View Paper
In both the control and experimental groups receiving betaine, liver betaine, BHMT and SAM were significantly higher than in their respective groups not receiving betaine.
Veterinary and human toxicology  •  1998  |  View Paper
A recent study in this laboratory demonstrated that dietary supplementation with betaine generated increased SAM in the liver and protected against ethanol-induced steatosis.
Alcoholism, clinical and experimental research  •  1997  |  View Paper
High-pressure liquid chromatography (HPLC) assessment of the effect of BET on sulfur-containing amino acid metabolism showed that BET increased the levels of nonenzymatic antioxidants, S-adenosylmethionine (SAM) and methionine (p < 0.05), via the regulation of the methionine-omocysteine cycle.
Journal of agricultural and food chemistry  •  2016  |  View Paper
Conclusions Combinations of SAMe with taurine and/or betaine have a hepatoprotective effect against ethanol-induced liver injury by maintaining GSH homeostasis.
Journal of cancer prevention  •  2016  |  View Paper
In addition, pretreatment of SAMe with taurine and/or betaine prevented the excessive increase in inflammatory mediators produced by LPS or polyI:C treatment.
Journal of cancer prevention  •  2016  |  View Paper
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