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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Betaine
drug:
Methotrexate
Research Papers that Mention the Interaction
“ Betaine also merits evaluation as an adjuvant to methotrexate and niacinamide therapies.”
Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy.“ MTX treatment alone lowered hepatic concentrations of PCho (to 48% control), GroPCho (to 69% control), betaine (to 55% control), and AdoMet (to 75% control).”
“Therefore, MTX depleted hepatic PCho, GroPCho, and betaine by a mechanism that was different from that of choline deficiency.”
Effects of choline deficiency and methotrexate treatment upon rat liver.
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