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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Betaine and Methotrexate



Research Papers that Mention the Interaction

Betaine also merits evaluation as an adjuvant to methotrexate and niacinamide therapies.
Medical hypotheses  •  2000  |  View Paper
MTX treatment alone lowered hepatic concentrations of PCho (to 48% control), GroPCho (to 69% control), betaine (to 55% control), and AdoMet (to 75% control).
Therefore, MTX depleted hepatic PCho, GroPCho, and betaine by a mechanism that was different from that of choline deficiency.
The Journal of nutritional biochemistry  •  1990  |  View Paper