Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Betaine and Methionine

supplement:

Betaine

supplement:

Methionine

Research Papers that Mention the Interaction

In plasma, betaine significantly lowered total homocysteine (but not to the normal range) and had a variable effect on methionine.
Pediatric Research  •  1997  |  View Paper
Moreover, betaine acutely reduces the increase in homocysteine after methionine loading by up to 50%, whereas folic acid has no effect.
Current drug metabolism  •  2005  |  View Paper
The inverse associations of methionine and total methyl donors including choline, betaine and methionine with pancreatic cancer risk in both cohorts support that DNA repair and methylation play an important role against the development of pancreatic cancer.
International journal of cancer  •  2020  |  View Paper
Treatment with hydroxocobolamin, betaine , and folinic acid initiated at 28 hours of life lead to rapid reduction in plasma homocysteine and increased serum methionine concentrations.
Journal of inherited metabolic disease  •  2019  |  View Paper
Use of betaine in the presence of elevated plasma methionine may increase the risk of reversible CWMLs in some CBS-deficient patients.
The Tohoku journal of experimental medicine  •  2015  |  View Paper
Dietary intakes of betaine and methionine were significantly higher in the twin with lower stage of AMD (P = 0.009) and smaller drusen area (P = 0.03), respectively.
Ophthalmology  •  2011  |  View Paper
Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine , SAM, SAM:SAH, and glutathione:GSSG and a decrease in SAH (n = 35).
The American journal of clinical nutrition  •  2007  |  View Paper
In all affected children, treatment with betaine (534+/-222 mg/kg/day) increased plasma S-adenosylmethionine, improved markers of tissue methyltransferase activity, and resulted in a threefold increase of calculated brain methionine uptake.
Molecular genetics and metabolism  •  2007  |  View Paper
Betaine does raise the methionine level and cerebral edema has occurred when plasma methionine exceeds 1000 micromol/L. Thus the plasma methionine as well as homocysteine must be monitored in patients receiving betaine.
Molecular genetics and metabolism  •  2006  |  View Paper
Betaine and choline can lower fasting tHcy concentrations to a similar extent as folic acid, particularly in the setting of a high intake of methionine.
Seminars in vascular medicine  •  2005  |  View Paper
Show More