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“The inverse associations of methionine and total methyl donors including choline, betaine and methionine with pancreatic cancer risk in both cohorts support that DNA repair and methylation play an important role against the development of pancreatic cancer.”
International journal of cancer • 2020 | View Paper
“Treatment with hydroxocobolamin, betaine , and folinic acid initiated at 28 hours of life lead to rapid reduction in plasma homocysteine and increased serum methionine concentrations.”
The Tohoku journal of experimental medicine • 2015 | View Paper
“Dietary intakes of betaine and methionine were significantly higher in the twin with lower stage of AMD (P = 0.009) and smaller drusen area (P = 0.03), respectively.”
“Supplementation with lecithin, choline, or betaine resulted in a significant increase in plasma methionine , SAM, SAM:SAH, and glutathione:GSSG and a decrease in SAH (n = 35).”
The American journal of clinical nutrition • 2007 | View Paper
“In all affected children, treatment with betaine (534+/-222 mg/kg/day) increased plasma S-adenosylmethionine, improved markers of tissue methyltransferase activity, and resulted in a threefold increase of calculated brain methionine uptake.”
Molecular genetics and metabolism • 2007 | View Paper
“ Betaine does raise the methionine level and cerebral edema has occurred when plasma methionine exceeds 1000 micromol/L. Thus the plasma methionine as well as homocysteine must be monitored in patients receiving betaine.”
Molecular genetics and metabolism • 2006 | View Paper
“ Betaine and choline can lower fasting tHcy concentrations to a similar extent as folic acid, particularly in the setting of a high intake of methionine.”