“Accordingly, betaine might have potential to be an adjunct to ketamine treatment for depression.”
“The antidepressant-like responses to betaine combined with ketamine were stronger than their individual effects.”
“These findings revealed that betaine could enhance the antidepressant-like effects, yet block the psychotomimetic effects of ketamine , suggesting that betaine can be considered as an add-on therapy to ketamine for treatment-resistant depression and suitable for the treatment of depressive symptoms in patients with schizophrenia.”