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“Long-term subcutaneous administration of hydroxocobalamin in combination with oral betaine and folic acid resulted in clinical and biological improvement in both patients.”
American journal of kidney diseases : the official journal of the National Kidney Foundation • 2005 | View Paper
“Increasing the dosage of hydroxycobalamin from 1 to 2.5, then 5 mg daily together with betaine , further reduced homocysteine levels (boy from 118 to 23 microM and girl from 59 to 14 microM).”
American journal of medical genetics • 2002 | View Paper
“While there is no cure, combined treatment with intramuscular hydroxycobalamin and oral betaine may reduce the severity of symptoms and improve clinical outcome.”