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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Betaine and Gamma-Aminobutyric Acid

supplement:

Betaine

Research Papers that Mention the Interaction

The substrate specificity of the high-affinity transporter was further studied and Gly-Sar, Leucine, gaboxadol, sarcosine, lysine, betaine , 5-hydroxythryptophan, proline and glycine reduced the GABA uptake to approximately 44-70% of the GABA uptake in the absence of inhibitor.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V  •  2012  |  View Paper
Accordingly, [3H]GABA uptake was also inhibited by betaine , and reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis of total RNA from U373 MG cells with specific BGT‐1 primers resulted in the amplification of a 440 bp fragment that was further characterized by restriction analysis and sequencing.
Journal of neuroscience research  •  2002  |  View Paper
GABA uptake exhibited the kinetics of high affinity transport and could be partly (20%) inhibited by betaine (IC50 142 μM), β-alanine (30%) and almost fully (90%) inhibited by SKF 89976-A (IC50 0.8 μM) or nipecotic acid and guvacine at 1 mM concentrations (95%).
Neurochemical Research  •  2010  |  View Paper
Low affinity GABA transporters GAT2 and GAT3 were inhibited most effectively by betaine and beta-alanine, respectively.
The Journal of biological chemistry  •  1993  |  View Paper