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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Betaine and Folate

supplement:

Betaine

supplement:

Folate

Research Papers that Mention the Interaction

Betaine correlated positively with folate (β=0.133) and negatively with tHcy (β=–0.194) ratio.
Clinical chemistry and laboratory medicine  •  2013  |  View Paper
Supplementation of folate-deprived 10C … 20C with 1% betaine significantly suppressed folate deprivation-induced hyperhomocysteinemia, but the extent of suppression was partial or limited, especially in rats fed 10C, the suppression of plasma homocysteine increment being 48.5% in rats fed 10C and 69.7% in rats fed 20C.
Journal of nutritional science and vitaminology  •  2012  |  View Paper
Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations.
Autism research and treatment  •  2013  |  View Paper
Dimerization of folate , monitored by nuclear magnetic resonance, was weakened 2-3-fold upon addition of betaine or dimethyl sulfoxide (DMSO), supporting preferential interaction of either osmolyte with the monomer (as it possesses a larger surface area).
Osmotic stress experiments also showed that betaine , DMSO, and sucrose preferentially interact with folate.
Biochemistry  •  2012  |  View Paper