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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Beta Carotene
drug:
Simvastatin
Research Papers that Mention the Interaction
“ Simvastatin decreased levels of total cholesterol by 20.8%, LDL cholesterol …%, apolipoprotein B by 22.4%, alpha-tocopherol by 16.2%, beta-carotene by 19.5%, and ubiquinol-10 by 22.0% (P<.001 for all) … by 7.0% (P<.001) and serum insulin by 13.2% (P =.005).”
Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial.“The addition of antioxidant vitamins (vitamin E, vitamin C, beta-carotene , and selenium) to the SN combination blunted the favorable effect of SN on clinical outcomes and angiographic measurements.”
“At the same time, in animals receiving simvastatin in combination with antioxidant vitamins (vitamins E and C, provitamin A ) and selenium, the period of induction of oxidation increased by 3.3 times.”
Effect of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors and antioxidant vitamins on free radical lipid oxidation in rat liver.
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