Possible Interaction: Berberine and Verapamil

“However, no significant concentration dependency for the permeability (P(app)) of berberine was observed for B-A transport over a concentration …) value of berberine for the carrier system is greater than 300 microM. Well-documented P-glycoprotein (P-gp) substrates such as verapamil, … berberine , whereas tetraethylammonium and … the transport.”

“ConclusionThe augmentative outcome of verapamil on the neuroprotective effect of berberine can be speculated due to the inhibition of P-gp efflux mechanism and the prevention of calcium homeostasis alteration.”

“Further, treatment of berberine (25 and 50 mg/kg) with verapamil (2.5 and 5.0 mg/kg) combinations respectively significantly potentiated their neuroprotective effect which was significant as compared to their effect per se in ICV-STZ-treated animals.”

“Thus, there is a strong scientific rationale to explore the interaction of berberine with verapamil as a possible neuroprotective strategy.”

“The findings suggested that the combination of berberine with verapamil , which could enhance its brain uptake, will surely provide a greater impact in neroprotection drug discovery for search of such combination.”

“There is a strong possibility of improved brain bioavailabity of berberine when combined with verapamil.”

“… berberine … verapamil improved the neurological outcome in a battery of behavioral paradigms, improved spatial memory in Morris water maze task, ameliorated the oxidative-nitrosative stress, increased … tumor necrosis factor-alpha, interleukin-1 beta and caspase-3 levels in brain tissues as compared to berberine alone group in ischemic rats.”

“The results showed that metabolic inhibitor KCN and P-glycoprotein inhibitor verapamil could increase berberine concentration within the neurons, indicating that efflux of berberine was energy-dependent and P-glycoprotein was likely to be involved.”