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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Berberine
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“We also found that BBR significantly decreased the levels of C-terminal fragments of APP and the hyperphosphorylation of APP and tau via the Akt/glycogen synthase kinase 3 signaling pathway in N2a mouse neuroblastoma cells stably expressing human Swedish mutant APP695 (N2a-SwedAPP).”
Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model“According to our study, berberine did not only significantly improve 3×Tg AD mice's spatial learning capacity and memory retentions, but also attenuated the hyperphosphorylation of tau.”
“Moreover, berberine reduced the level of tau through an autophagy-based route.”
“Thus, our results suggest that berberine could mitigate cognitive decline by simultaneously targeting the hyperphosphorylation of tau and the autophagic clearance of tau in AD mice.”
Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance.“ Berberine significantly attenuated memory impairment, axonopathy, and tau hyperphosphorylation, and also restored PI3K/Akt/GSK3β signaling pathway in T2D rats.”
“ Berberine attenuated tau hyperphosphorylation and cytotoxicity induced by CA.”
“ Berberine also effectively decreased the expression of hippocampal tau protein, phosphorylated Tau , and increased insulin receptor antibodies.”
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action.“ Berberine attenuated tau hyperphosphorylation and cytotoxicity induced by CA.”
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