“The individual pharmacogenetic profile of our patient might be helpful for interpreting the significant tacrolimus– berberine interaction.”
“To our knowledge, our report demonstrates for the first time that berberine strongly affects the disposition of tacrolimus , with clinically relevant increase in tacrolimus C0 concentrations and renal toxicity.”
“We report a significant in vivo interaction between tacrolimus and berberine , both substrates of CYP3A4-A5, resulting in rapid increase in tacrolimus blood concentrations.”
“We report here a welldocumented interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome.”