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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Berberine and Sirolimus

supplement:

Berberine

Research Papers that Mention the Interaction

Flow cytometric analyses showed that berberine significantly augmented the KYSE-70 apoptotic population at 12 and 24 h post-treatment, when compared with control … 24 h, P < 0.01), and berberine-induced apoptotic effect was stronger at 24 h compared with 12 h. Western blotting showed that berberine … rapamycin ….
World journal of gastroenterology  •  2017  |  View Paper
Results showed that BBR may inhibit protein synthesis, histone deacetylase (HDAC), or AKT/mammalian target of rapamycin (mTOR) pathways.
Scientific reports  •  2014  |  View Paper
In conclusion, the findings of the present study suggest that the combined use of rapamycin and berberine may improve HCC therapy through synergistically inhibiting the mTOR signaling pathway, which is at least in part, mediated through CD147.
The combined use of rapamycin and berberine was found to have a synergistic cytotoxic effect, with berberine observed to maintain the cyotoxic effect of rapamycin on HCC cells at a lower rapamycin concentration.
Molecular medicine reports  •  2014  |  View Paper
Further, the protective effect of BBR was inhibited by rapamycin.
Bioengineered  •  2021  |  View Paper