Possible Interaction: Berberine and Serotonin

“Our results showed that chronic administration of 100 mg/kg/day berberine not only reduced glucose levels, but also inhibited the augmented contractile function of cerebral artery to KCl and 5-hydroxytryptamine (5-HT) in diabetic rats.”

“ Berberine , an isoquinoline alkaloid is reported to modulate several neurotransmitter systems like N-methyl-D-aspartate, nitric oxide and serotonin , which modulate convulsions.”

“ Berberine is also demonstrated to modulate the activity of several neurotransmitter systems like, dopamine, nitric oxide, serotonin , and NMDA, which are implicated in rewarding effects of ethanol.”

“Our findings demonstrated that berberine exerted antidepressant-like effect in various behavioural paradigms of despair possibly by modulating brain biogenic amines (norepinephrine, serotonin or dopamine) and further, the antidepressant-like effect of berberine in the forced-swim test involved an interaction with the L-arginine-NO-cGMP pathway.”

“ Berberine also relaxed the contraction of anococcygeus muscle induced by 5-hydroxytryptamine.”

“ Berberine also relaxed the contraction of anococcygeus muscle induced by 5-hydroxytryptamine.”

“In mice, administration of BBR in the dose range of 5-10m/kg has been reported to raise the levels of serotonin (47%), dopamine (31%), and norepinephrine (29%) in CNS to allay depression.”