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Last Updated: 4 years ago

Possible Interaction: Berberine and Regorafenib

supplement:

Berberine

Research Papers that Mention the Interaction

Compared with regorafenib alone, the combined treatment of BBR and regorafenib significantly inhibited the proliferation of HCC cells and induced cellular apoptosis.
Meanwhile, the combined treatment group with BBR (10mg/kg/day) and regorafenib (5mg/kg/day) had a dramatic inhibitory effect on the growth of HCC xenograft tumors in nude mice.
Taken together, this study demonstrated that BBR enhanced the anti-HCC effect of regorafenib both in vitro and in vivo.
The synergistic anti-tumor effect of BBR and regorafenib might be related to the up-regulation of hsa_circ_0032029 and hsa_circ_0008928 in HCC cells.
We found that BBR enhanced the cytotoxicity of regorafenib in HCC cells.
Frontiers in Pharmacology  •  2021  |  View Paper