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Last Updated: 2 years ago

Possible Interaction: Berberine and Pyrimethamine

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supplement:

Berberine

drug:

Pyrimethamine

Research Papers that Mention the Interaction

“In rats, we found that pyrimethamine (PYR), an inhibitor of Mate1, increased hepatic and renal distribution of BBR and decreased systematic excretion of BBR.”

The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine

Xenobiotica; the fate of foreign compounds in biological systems • 2018 | View Paper

“In animal experiments, compared with the berberine alone group, the cumulative urinary excretion of berberine significantly decreased in the corticosterone or pyrimethamine pretreatment groups.”

Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats

Biopharmaceutics & drug disposition • 2018 | View Paper

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