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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Berberine
supplement:
Oligomeric Procyanidin Complex
Research Papers that Mention the Interaction
“In summary, this study demonstrated that combination of BB with OPCs could significantly improve the pharmacokinetics and hypoglycemic efficacy of BB, which is valuable for future exploration of the combination of BB and OPCs as oral hypoglycemic agents.”
“In the in vitro experiments, OPCs significantly inhibited the efflux and increased the uptake of the P-glycoprotein (P-gp) substrate rhodamine-123 (R123) and BB in Caco-2 intestinal cells.”
“The inhibition of BB efflux by OPCs was translated into the improved pharmacokinetics in vivo.”
“The results revealed that OPCs considerably potentiated the hypoglycemic efficacy of BB in diabetic db/db mice.”
“This study investigated the possible enhancement of berberine’s (BB) hypoglycemic activity by oligomeric proanthocyanidins (OPCs) and its underlying mechanism.”
“When co-administered, OPCs obviously increased the average maximum concentration of BB in mice.”
Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins
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