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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Berberine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“In both macrophage cell types, berberine inhibited the LPS-induced nitric oxide ( NO ) production and inducible NO synthase (iNOS) protein expression, but it had no effect on iNOS mRNA transcription.”
Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages“The results demonstrated that berberine significantly elevated NO levels and reduced the production of ROS.”
“In addition, BER restored colonic antioxidant capacity through elevation of GSH level and antioxidant enzymatic activities (SOD, CAT, GPx, and GR) together with reductions of both MDA and NO levels.”
Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways“Observations revealed that, the BBR significantly downregulated VCL‐increased IL‐6, TNF‐α and NO levels, upregulated the CuZn SOD, MnSOD, EC‐SOD and GSH‐px mRNA level, decreased testicular MDA content, enhanced serum testosterone level and ameliorated testicular TAC, SOD and GSH‐px levels.”
“… BBR , OBB and DHBB (1.25, 2.5 and 5 μM) pretreatment significantly decreased the … (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandinE2 (PGE2) and nitricoxide ( NO ), and inhibited the mRNA expressions of cyclooxygenase-2 (COX-2) …-dependent manner, with relative efficiency of OBB > BBR > DHBB.”
“Finally, berberine reduced miR-133a expression, and increased both BH4 levels and NO production in cultured endothelial cells treated with high glucose.”
“The major compounds, berberine and palmatine, decreased the viability and NO levels of cells.”
“It seems that blockade of NO production by berberine may also participate in oligodendroglial cell protection against oxygen-glucose deprivation/reperfusion-induced insult.”
“Our results demonstrated that berberine (2 μM) significantly decreased NO production during 30 min oxygen-glucose deprivation/reperfusion.”
“ BN (100mg/kg bwt) treatment inhibited lipid peroxidation and nitric oxide production, whereas it increased glutathione content.”
“ Berberine significantly inhibited the LPS-stimulated NO production and HMGB1 release in macrophages.”
“The inhibitory effect of berberine on LPS-stimulated NO and HMGB1 release was reversed by siRNA-Nrf2, SB203580 (p38 MAPK inhibitor) and zinc protoporphyrin (ZnPP; HO-1 inhibitor) within macrophages.”
“We investigated the molecular mechanism by which berberine reduces nitric oxide (NO) expression and high-mobility group box 1 (HMGB1) release in lipopolysaccharide (LPS)-induced macrophages.”
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