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Last Updated: 2 months ago

Possible Interaction: Berberine and Nitric Oxide



Research Papers that Mention the Interaction

In both macrophage cell types, berberine inhibited the LPS-induced nitric oxide ( NO ) production and inducible NO synthase (iNOS) protein expression, but it had no effect on iNOS mRNA transcription.
The Journal of Pharmacology and Experimental Therapeutics  •  2016  |  View Paper
The results demonstrated that berberine significantly elevated NO levels and reduced the production of ROS.
Mediators of inflammation  •  2013  |  View Paper
Observations revealed that, the BBR significantly downregulated VCL‐increased IL‐6, TNF‐α and NO levels, upregulated the CuZn SOD, MnSOD, EC‐SOD and GSH‐px mRNA level, decreased testicular MDA content, enhanced serum testosterone level and ameliorated testicular TAC, SOD and GSH‐px levels.
Andrologia  •  2019  |  View Paper
BBR , OBB and DHBB (1.25, 2.5 and 5 μM) pretreatment significantly decreased the … (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandinE2 (PGE2) and nitricoxide ( NO ), and inhibited the mRNA expressions of cyclooxygenase-2 (COX-2) …-dependent manner, with relative efficiency of OBB > BBR > DHBB.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2019  |  View Paper
The major compounds, berberine and palmatine, decreased the viability and NO levels of cells.
Journal of medicinal food  •  2018  |  View Paper
It seems that blockade of NO production by berberine may also participate in oligodendroglial cell protection against oxygen-glucose deprivation/reperfusion-induced insult.
Our results demonstrated that berberine (2 μM) significantly decreased NO production during 30 min oxygen-glucose deprivation/reperfusion.
Pakistan journal of biological sciences : PJBS  •  2014  |  View Paper
BN (100mg/kg bwt) treatment inhibited lipid peroxidation and nitric oxide production, whereas it increased glutathione content.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2014  |  View Paper
Berberine significantly inhibited the LPS-stimulated NO production and HMGB1 release in macrophages.
The inhibitory effect of berberine on LPS-stimulated NO and HMGB1 release was reversed by siRNA-Nrf2, SB203580 (p38 MAPK inhibitor) and zinc protoporphyrin (ZnPP; HO-1 inhibitor) within macrophages.
We investigated the molecular mechanism by which berberine reduces nitric oxide (NO) expression and high-mobility group box 1 (HMGB1) release in lipopolysaccharide (LPS)-induced macrophages.
Biochemical and biophysical research communications  •  2013  |  View Paper
The productions of NO and iNOS were repressed by berberine compared with those in the infected group (P<0.01).
Chinese journal of integrative medicine  •  2011  |  View Paper
In IL‐1β‐induced rat articular chondrocytes, berberine decreased IL‐1β‐induced GAG release and NO production.
Phytotherapy research : PTR  •  2011  |  View Paper
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