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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Recently, berberine was reported to inhibit the rewarding effects of drugs of abuse such as cocaine, morphine , and nicotine.”
Inhibitory effect of berberine on the motivational effects of ethanol in mice“Injection of berberine (10 and 20 mg/kg) 2 h before the morphine administration reduced acquisition of morphine-induced CPP.”
“Objective: It has been shown that berberine , a major component of Berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of morphine.”
Effects of berberine on acquisition and reinstatement of morphine-induced conditioned place preference in mice“Taken together, these findings demonstrated that BER administration significantly reduced morphine withdrawal-associated behaviors following discontinuation of repeated morphine administration in rats, possibly through modulation of hypothalamic CRF and the central noradrenergic system.”
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