supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Berberine
drug:
Lovastatin
Research Papers that Mention the Interaction
“Background: We assumed that the pharmacokinetics of lovastatin could be changed by the induction effect of berberine.”
“Conclusions: From the in vivo pharmacokinetics study … HepG2 cell metabolism study in vitro, berberine could be an … the metabolism of lovastatin according to our previous research on berberine induction effects on HepG2 cells, which may … to the fact that berberine possesses induction effects through the CYP 450 3A4 enzyme.”
“The metabolism parameters of lovastatin such as CL, Vmax and Km were increased after the induction of berberine.”
In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies“The obtained results indicated that the effect of berberine is not dependent on blocking protein prenylation in cells, and the toxic effect of lovastatin combined with berberine is reversed by addition of the substrates of this pathway to the level brought out by lovastatin alone.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback