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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Discussion and conclusion: We infer that BBR might increase the plasma concentration of losartan and decrease the concentration of EXP3174 through inhibiting the activity of CYP3A4 or CYP2C9.”
“However, the potential herb–drug interaction between losartan and BBR is unknown.”
“Results: The Cmax (1.26 ± 0.37 versus 1.96 ± 0.45 ….25 ± 0.89 versus 12.70 ± 1.42 mg h/L) of losartan … BBR compared to the control, while the Cmax (0.97 ± 0.15 versus … EXP3174 was significantly decreased compared to the control (p < 0.05).”
“The inhibitory effects of BBR on the metabolic stability of losartan were investigated using rat liver microsomes.”
Effects of berberine on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism
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