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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Berberine
drug:
Ketoconazole
Research Papers that Mention the Interaction
“After oral co‐… mg/kg KTZ with … BBR , the average area under the curve (AUC) and the maximum concentration (Cmax) for KTZ increased to 215% and 449% (p < 0.…, in male rats and 157% and 172% (p < 0.05), respectively, in female rats, compared with those administered KTZ alone.”
“In rat liver microsomes, inhibitory concentration (IC)50 of BBR inhibiting KTZ depletion was determined to be 103 µ m. These resulting pharmacokinetic interactions may benefit their pharmacodynamic synergism to a certain extent.”
“Recently, a synergistic antifungal effect of KTZ combined with BBR has been revealed.”
Drug–drug Interactions between Ketoconazole and Berberine in Rats: Pharmacokinetic Effects Benefit Pharmacodynamic Synergism“α-Naphthoflavone, miconazole, and ketoconazole , which are known inhibitors of cytochrome P450, interfered with BD3100 metabolism of berberine in resting cells.”
11-Hydroxylation of Protoberberine by the Novel Berberine-Utilizing Aerobic Bacterium Sphingobium sp. Strain BD3100.
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