Possible Interaction: Berberine and Interferons

“Oral … of BBR inhibited the NF-κB signal transduction pathway, reduced the … of pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, interferon-γ , and tumor necrosis factor-α], promoted the expression of anti-inflammatory cytokines (IL-10 and transforming growth factor-β), and improved the terminal ileum tissue inflammation.”

“Serum levels of tumor necrosis factor (TNF)-alpha, interferon (IF)-gamma, interleukin (IL)-2, and IL-1beta were reduced by berberine pre-treatment; levels of serum IL-10, an anti-inflammatory cytokine, was elevated.”

“Our findings also demonstrate that berberine significantly down‐regulates LPS‐ or interferon (IFN)‐γ‐induced nitric oxide synthase (iNOS) and cyclo‐oxygenase‐2 (COX‐2) expression in BV‐2 microglia cells.”

“The administration of berberine significantly reduced plasma TNF-α, IFN-γ , and NO levels, but did not suppress plasma IL-12 levels in mice exposed to LPS.”

“Importantly, berberine pretreatment of macrophages increased their ability to induce interferon‐γ (IFN‐γ) and reduced their ability to induce IL‐4 in antigen‐primed CD4+ T cells.”

“The results showed that BBR could significantly improve the pathological characteristics of gastric tissue, alleviate the serum biochemical indexes and reduce the mRNA expression of nuclear factor-κB, tumor necrosis factor-α, Cyclooxygenase-2, monocyte chemoattractant protein-1, Interleukin-17A and I interferon-γ.”