Possible Interaction: Berberine and Hydrogen Peroxide

“Concomitantly, berberine attenuates the inflammatory response, evidenced as decreased messenger RNA (mRNA) expression of IL-1β, IL-6, TNFα, IFNγ, and iNOS, as well as the oxidative stress response, evidenced as impaired increase in malondialdehyde, nitrate, and H2O2 and as prevented decrease in glutathione and catalase activity.”

“Pre-treatment of D407 cells with BBR significantly suppressed H2O2-induced cell apoptosis by restoring abnormal changes in nuclear morphology, preventing the decline of mitochondrial membrane potential, reducing lactate dehydrogenase release and inhibiting caspase 3/7 activities induced by H2O2.”

“We have previously reported that BBR attenuated H2O2 neurotoxicity via activating the PI3K/Akt/Nrf2-dependent pathway.”

“Results from cell viability and apoptosis assay showed that in cells exposed to hydrogen peroxide (H2O2), the pretreatment of 12 μM BBR could increase cell viability by 19.10 ± 7.40% and reduce apoptotic cells by 7.91 ± 0.78%.”

“At the same time, berberine increased the activities of GSH-Px and CAT (P < 0.01) and slightly lowed the content of H2O2 in the kidney tissues.”

“However, … Ber (10-1000 … effects of H2O2 , with increased cell viability (P<0.05 or P<0.01), NO production (P<0.01), and SOD activity (P<0.… release and MDA content (both P<0.01).Conclusion:Ber could produce its antioxidant action on oxidative stress-induced cultured CCSMC.”

“A stronger chemiluminescence (CL) was observed when hydrogen peroxide was mixed with nitrite and berberine in sulfuric acid solution.”