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Last Updated: 2 years ago

Possible Interaction: Berberine and Glutathione

supplement:

Berberine

supplement:

Glutathione

Research Papers that Mention the Interaction

Concomitantly, berberine attenuates the inflammatory response, evidenced as decreased messenger RNA (mRNA) expression of IL-1β, IL-6, TNFα, IFNγ, and iNOS, as well as the oxidative stress response, evidenced as impaired increase in malondialdehyde, nitrate, and H2O2 and as prevented decrease in glutathione and catalase activity.
Parasitology Research  •  2015  |  View Paper
In addition, checkerboard microdilution assay showed that addition of antioxidant ascorbic acid or reduced glutathione reduced the synergistic antifungal activity of FLC + BBR significantly.
Journal of proteome research  •  2009  |  View Paper
The results revealed that BBR significantly decreased the serum levels of alanine transaminase, aspartate transaminase and alkaline phosphatase, and increased those of glutathione and superoxide dismutase, but decreased malondialdehyde activity in hepatic tissue, and significantly decreased the reactive oxygen species level in hepatocytes.
Molecular medicine reports  •  2019  |  View Paper
Furthermore, berberine lowered hippocampal activity of acetylcholinesterase (AChE), malondialdehyde (MDA), protein carbonyl, activity of caspase 3, and DNA fragmentation and improved antioxidant capacity through enhancing glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase, and glutathione ( GSH).
Metabolic Brain Disease  •  2018  |  View Paper
Moreover, the decrease in total thiols, and the reduced glutathione and glutathione S-transferase activity in the cerebral cortex and hippocampus of ICV-STZ rats, was prevented by BRB treatment.
Psychopharmacology  •  2018  |  View Paper
The increased levels of lipid peroxide (malonaldehyde), pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), enzymatic antioxidants (SOD and CAT), non-enzymatic antioxidants GSH and vitamin C) and transcription factor NF-κB were decreased significantly by administration of berberine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2017  |  View Paper
BBR attenuated reactive oxygen species production, antioxidant defense ( GSH and SOD) and oxidant-sensitive proteins (Nrf2 and HO-1), which also were blocked by LY294002 (an inhibitor of PI3K) in HG-treated NRK-52E and HK-2 cells.
Apoptosis  •  2016  |  View Paper
In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase.
Biological Research  •  2013  |  View Paper
In H(2)O(2)-treated cells, BBR significantly attenuated ROS production and increased cell viability, antioxidant defense ( GSH and SOD) and oxidant-sensitive proteins (HO-1 and Nrf2), which also were blocked by LY294002.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2012  |  View Paper
Berberine also attenuated the t-BHP-induced depletion of glutathione (GSH) and induced a high level of DNA repair synthesis.
Archives of Toxicology  •  2002  |  View Paper
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