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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Berberine and Glucagon

supplement:

Berberine

Research Papers that Mention the Interaction

Berberine caused significant PEPCK1 ubiquitination and degradation by antagonizing glucagon and was accompanied by high levels of PEPCK1 acetylation.
Here we show a new mechanism by which berberine antagonizes glucagon signaling and find that SIRT3 is involved in the hypoglycemic effect of berberine.
Endocrine  •  2018  |  View Paper
Another important consideration that berberine is having stimulatory effect on glucagon like peptide release and insulin sensitization that will be helpful for decreasing glucose levels and therefore, may exerts osteogenesis.
Medical hypotheses  •  2012  |  View Paper
The data support the hypothesis that the anti-diabetic effects of BBR may partly result from enhancing GCG secretion.
The results indicated that BBR treatment significantly increased GCG levels in plasma and intestine (P<0.05) accompanied with the increase of proglucagon mRNA expression and the number of L-cell compared with the controls (P<0.05).
The Journal of endocrinology  •  2009  |  View Paper