Possible Interaction: Berberine and Fluorouracil

“Further, we observed that co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents, including fluorouracil (5-FU), camptothecin (CPT), and paclitaxel (TAX).”

“The combination of berberine and 5-fluorouracil (5-FU) had a higher inhibitory rate (59.8 %) than the berberine group (36.4 %, P = 0.01), but no significant difference was observed between the 5-FU group (43.0 %, P = 0.06) and the combination group.”

“Besides, it was aimed to investigate whether berberine could enhance the anti-cancer effect of 5-fluorouracil and cisplatin in HEP2.”

“Moreover, a down regulation of these genes caused by cisplatin or 5-fluorouracil , treatment of election in laryngeal cancers was enhanced by a 4h pre-treatment with berberine.”

“ 5-FU in combination with berberine or curcumin showed a synergistic inhibition of survivin and STAT3 level resulting in enhanced cell death in gastric cancer cells.”

“ Berberine , a botanical alkaloid, was reported to enhance chemosensitivity to 5‑fluorouracil and doxorubicin by suppressing NF‑κB activation.”

“Importantly, BBR significantly increased the levels of butyrate and glutamine in feces from 5-Fu treated rats.”

“Results showed that BBR treated rats displayed less weight loss, lower diarrhea score and longer colon length in 5-Fu treated rats.”

“As a result, methanol extracts and three alkaloids berberine , coptisine, and palmatine isolated from Coptidis Rhizoma) enhanced effectively the skin permeation of 5-fluorouracil , which is taken as a hydrophilic permeant.”

“Combinations of COP or BER with chemotherapeutic agents ( 5-FU , CPT, and TAX) exhibited a stronger inhibitory effect on A549 cell growth.”