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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Berberine and Ergosterol

supplement:

Berberine

Research Papers that Mention the Interaction

Results showed that berberine affects synthesis of membrane ergosterol dose-dependently and induces increased membrane permeability causing loss of intracellular material to the outer space (DNA/protein leakage).
BMC Complementary and Alternative Medicine  •  2017  |  View Paper
In addition, exogenous ergosterol could decrease intracellular BBR concentration and increase the expression of drug efflux pump genes, further reducing the susceptibility of C. albicans to BBR.
Real-time RT-PCR revealed a global upregulation of ergosterol synthesis genes in response to BBR exposure.
The ergosterol quantitative analysis showed that the BBR monotreatment could increase the content of cellular ergosterol.
Front. Cell. Infect. Microbiol.  •  2017  |  View Paper