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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Further, the levels of dopamine and norepinephrine were also significantly decreased by berberine administration (5 and 30mg/kg) in the striatal regions of 6-OHDA-lesioned rats.”
Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease“ Berberine is also demonstrated to modulate the activity of several neurotransmitter systems like, dopamine , nitric oxide, serotonin, and NMDA, which are implicated in rewarding effects of ethanol.”
“Our findings demonstrated that berberine exerted antidepressant-like effect in various behavioural paradigms of despair possibly by modulating brain biogenic amines (norepinephrine, serotonin or dopamine ) and further, the antidepressant-like effect of berberine in the forced-swim test involved an interaction with the L-arginine-NO-cGMP pathway.”
“These results give evidence that berberine and palmatine lead to decreased dopamine content by inhibition of TH activity but not by regulation of TH gene expression in PC12 cells.”
“In mice, administration of BBR in the dose range of 5-10m/kg has been reported to raise the levels of serotonin (47%), dopamine (31%), and norepinephrine (29%) in CNS to allay depression.”
Berberine in the Treatment of Neurodegenerative Diseases and Nanotechnology Enabled Targeted Delivery.“Moreover, 2,4,6-trimethyl-pyranylium tetrafluoroborate (TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry (MALDI-MS) imaging of dopamine identified elevated striatal dopamine levels in mouse brains with oral Enterococcus, and BBR strengthened the imaging intensity of brain dopamine.”
“The increased DA concentration during BER treatment may partly be attributed to mRNA expression of tyrosine hydroxylase and the DA transporter in the hippocampus, while BER exerted no significant effects on vesicular monoamine transporter mRNA expression in the hippocampus of rats with PTSD.”
“Objective: It has been shown that berberine , a major component of Berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of morphine.”
“Coptidis rhizoma (CR) and its main compound, berberine (BER) reduced the dopamine content in the central nervous system.”
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