Possible Interaction: Berberine and Dinoprostone

“Besides, BER could repress inflammatory markers tumour necrosis factor-α, interleukin-6 and IL-1β, as well as prostaglandin E2 , inducible nitric oxide synthase and cyclooxygenase-2.”

“Besides, BER could repress inflammatory markers tumour necrosis factor‐α, interleukin‐6 and IL‐1β, as well as prostaglandin E2 , inducible nitric oxide synthase and cyclooxygenase‐2.”

“Experimental studies indicated that berberine inhibited 5-LOX (100 μM) and PGE2 (50 μM) production by 72.2 and 72.0% and ferulic acid by 74.3 and 54.4% respectively.”

“In addition, BBR significantly suppressed the protein expression levels of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX)‑2 and elevated the content ratio of AA to prostaglandin E2 (PGE2).”

“The results of the present study demonstrated that elevation in the ratio of AA to PGE2 via suppression of the protein expression of cPLA2 and COX‑2 in the AA metabolic pathway is involved in the inhibitory effect of BBR in HCC.”

“In oral cancer cell line OC2 and KB cells, a 12 h berberine treatment (1, 10, and 100 microM) reduced prostaglandin E2 (PGE2) production dose-dependently with or without 12-O-tetradecanoylphorbol-13-acetate (TPA, 10 nM) induction.”

“Several compounds, such as berberine , berberrubine and epiberberine, dose-dependently inhibited PGE2 production in human KB cells, and the effects were similar in the presence or absence of TPA.”

“The active ingredients of HST were quantified by LC-MS/MS, and [6]-shogaol, [6]-gingerol, wogonin, baicalein, baicalin, and berberine were shown to reduce PGE2 production.”

“ PGE2 induced COX-2 and Mcl-1 expression and reversed the repressive effect of berberine on Mcl-1.”

“ BER significantly retrieved colon inflammation and mucosal damage indicated by inhibition of macroscopic score and lessened the levels of inflammatory biomarkers (IL-1β, IL-6, TNF-α, MPO, and PGE2).”

“… BBR , OBB and DHBB (1.25, 2.5 and 5 μM) pretreatment significantly decreased …-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandinE2 ( PGE2 ) and nitricoxide (NO), and inhibited the mRNA expressions of cyclooxygenase-2 (… a dose-dependent manner, with relative efficiency of OBB > BBR > DHBB.”

“The level of IL-6 and PGE2 were significantly increased in DN model group compared with normal group, BBR could apparently reduced the level of IL-6 and PGE2.”