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Last Updated: 2 years ago

Possible Interaction: Berberine and Digoxin

supplement:

Berberine

drug:

Digoxin

Research Papers that Mention the Interaction

Berberine inhibits P-gp and thereby increases the bioavailability of the P-gp substrate digoxin in rodents.
International journal of molecular sciences  •  2019  |  View Paper
After pretreatment with BBR (30, 100 mg x kg(-1)), the pharmacokinetic parameters of ig DIG were significantly altered.
CONCLUSION BB in creases bioavailability of DIG , w hich may be related to its inhibition effect on intestinal P-gp.
The AUC(0-t) of DIG with BBR increased by 33% and 70% (single), 27% and 75% (2-week), respectively.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica  •  2011  |  View Paper
In conclusion, berberine produced a dose‐dependent increased bioavailability of digoxin and cyclosporine A by inhibition of intestinal P‐gp.
Phytotherapy research : PTR  •  2009  |  View Paper
This berberine mixed micelle formulation had a mean size of 12 nm and increased the cellular accumulation of digoxin via P-gp inhibition.
Pharmaceutics  •  2020  |  View Paper