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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Berberine
drug:
Daunorubicin
Research Papers that Mention the Interaction
“For the case of daunomycin , the B-A flux, but not the apical-to-basolateral flux, was significantly increased after pretreatment of the cell monolayers with berberine.”
“However, no significant concentration dependency for the permeability (P(app)) of berberine was observed for B-A transport over a concentration range … berberine for the carrier system is greater than 300 microM. Well-documented P-glycoprotein (P-gp) substrates such as verapamil, daunomycin, … berberine , whereas tetraethylammonium and … the transport.”
“If this occurs in the gastrointestinal epithelial cells, the repeated administration of berberine may reduce the gastrointestinal absorption of P-gp substrates including chemotherapeutic agents such as daunomycin.”
P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers.
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