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Last Updated: a month ago

Possible Interaction: Berberine and Cyclosporine

supplement:

Berberine

Research Papers that Mention the Interaction

The present results suggest that BBR can increase the oral bioavailability of CsA at the dosage of 3 mg/kg.
Methods and findings in experimental and clinical pharmacology  •  2006  |  View Paper
After co-administration of BBR in six patients for 12 days, the mean AUC of CsA was increased by 34.5% (P<0.05).
In addition, the average percentage decrease in CL/F was 40.4% (P<0.05) and the peak-to-through fluctuation index was significantly reduced (P<0.01).ConclusionThe BBR can markedly elevate the blood concentration of CsA in renal-transplant recipients in both clinical and pharmacokinetic studies.
European Journal of Clinical Pharmacology  •  2005  |  View Paper
Increased CyA concentration has been reported in patients with grapefruit juice, chamomile, or berberine , and with cannabidiol or resveratrol in animal studies.
Journal of toxicology  •  2014  |  View Paper
Our studies indicated that berberine uptake was significantly suppressed by rifampicin, cyclosporine A and glycyrrhizic acid, which act as specific inhibitors of different Oatp isoforms (Oatp1a1, Oatp1a4 and Oatp1b2) in rat hepatocytes.
Our studies indicated that berberine uptake was significantly suppressed by rifampicin, cyclosporine A and glycyrrhizic acid, which act as specific inhibitors of different Oatp isoforms (Oatp1a1, Oatp1a4 and Oatp1b2) in rat hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems  •  2015  |  View Paper
In …, berberine serosal-… by cyclosporin A. In Ussing-type chambers, the rate of serosal-to-mucosal transport across rat ileum was 3-times greater than in the … decreased by cyclosporin A. In Caco-2 cells, berberine uptake was significantly increased by P-glycoprotein inhibitors and by monoclonal antibody C219.
Pharmacology & toxicology  •  2002  |  View Paper
In conclusion, berberine produced a dose-dependent increased bioavailability of digoxin and cyclosporine A by inhibition of intestinal P-gp.
administered CsA with a 2-week pretreatment with BBR increased by 62% and 43% (BBR 30 mg/kg, p < 0.05), 96% and 60% (BBR 100 mg/kg, p < 0.01), compared with the control.
Phytotherapy research : PTR  •  2009  |  View Paper
Moreover, berberine was processed through hepatobiliary excretion against a concentration gradient based on the bile-to-blood …(blood)); the active berberine efflux might be affected by P-gp and OCT since coadministration of berberine … CsA or quinidine at the same dosage of …) significantly decreased the berberine amount in bile.
Drug metabolism and disposition: the biological fate of chemicals  •  2004  |  View Paper