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Last Updated: 2 years ago

Possible Interaction: Berberine and Curcumin



Research Papers that Mention the Interaction

However, use of a formulation of curcumin with higher bioavailability or combining it with berberine as a co-treatment may be proving to be more efficacious against cancer.
PloS one  •  2019  |  View Paper
Our data also demonstrated that co-treatment of CUR and BBR strongly up-regulated phosphorylation of JNK and Beclin1, and decreased phosphorylated Bcl-2.
The results showed that CUR and BBR in combination synergistically inhibited the growth of both MCF-7 and MDA-MB-231 breast cancer cells than the compounds used alone.
These results strongly suggested that JNK/Bcl-2/Beclin1 pathway played a key role in the induction of ACD in breast cancer cells by co-treatment of CUR and BBR.
This prompted us to investigate the chemopreventive potential of co-treatment of CUR and BBR against breast cancers.
Scientific reports  •  2016  |  View Paper
The results had proven the synergetic anticancer activity of Berberine with Curcumin inducing cell death greater percentage of >77% when compared to pure curcumin with <54% and pure Berberine with <45% on average on all cell line models.
BioMed research international  •  2015  |  View Paper
Here, using a transgenic AD mouse model, we found that the combined berberine and curcumin treatment had a much better effect on improving the cognitive function of mice than the single-drug treatment, suggesting synergic effects of the combined berberine and curcumin treatment.
In addition, we found that the combined berberine and curcumin treatment had significant synergic effects on reducing soluble amyloid-β-peptide (1–42) production.
Taken together, the result of this study reveal the synergic effects and potential underlying mechanisms of the combined berberine and curcumin treatment in improving the symptoms of AD in mice.
Neurochemical Research  •  2020  |  View Paper
We conclude that combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin, and this enhanced effect is associated with oxidative stress, hepatic inflammation and lipid metabolism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2018  |  View Paper
However, discrepant bioavailability and biodistribution of BER and CUR remained an obstacle to achieve synergistic effects.
Journal of Nanobiotechnology  •  2021  |  View Paper