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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Berberine
drug:
Corticosterone
Research Papers that Mention the Interaction
“CONCLUSIONS The metabolism of sulfonylureas and be berine wa s affected when these com pounds we re co-incubated with each other.”
Effect of Berberine on In Vitro Metabolism of Sulfonylureas: A herb-drug interactions study.“The quantitative proteomics conjugated gene ontology analysis revealed the inhibitory effect of CORT on the expression of mitochondrial oxidative phosphorylation-related proteins, which can be antagonized by berberine (BBR) treatment.”
“In Madin‐Darby canine kidney (MDCK) cells stably expressing rat OCT2 (MDCK‐rOCT2) and kidney slices, saturable and non‐saturable uptake of berberine was observed, and corticosterone could inhibit the uptake of berberine , with IC50 values of 0.1 μm and 147.9 μm, respectively.”
“In animal experiments, compared with the berberine alone group, the cumulative urinary excretion of berberine significantly decreased in the corticosterone or pyrimethamine pretreatment groups.”
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