“Collectively, our data suggest that the combination therapy of BBR and DDP markedly enhanced OS cell death.”
“Furthermore, the results showed that the combination treatment of BBR and DDP enhanced the inhibition of cell migration and invasion and reversed the changes in nuclear morphology.”
“Mechanistically, the combination treatment of BBR and DDP inhibited the expression of MMP-2/9, Bcl-2, CyclinD1, and CDK4, enhanced the expression of Bax and regulated the activity of the MAPK pathway.”
“The combination treatment of BBR and DDP exerted a prominent inhibitory effect on proliferation and colony formation.”
“The results showed that the combination treatment of BBR and DDP induced apoptosis and cell cycle arrest in the G0/G1 phase.”