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Last Updated: 3 years ago

Possible Interaction: Berberine and Cisplatin

supplement:

Berberine

Research Papers that Mention the Interaction

Collectively, our data suggest that the combination therapy of BBR and DDP markedly enhanced OS cell death.
Furthermore, the results showed that the combination treatment of BBR and DDP enhanced the inhibition of cell migration and invasion and reversed the changes in nuclear morphology.
Mechanistically, the combination treatment of BBR and DDP inhibited the expression of MMP-2/9, Bcl-2, CyclinD1, and CDK4, enhanced the expression of Bax and regulated the activity of the MAPK pathway.
The combination treatment of BBR and DDP exerted a prominent inhibitory effect on proliferation and colony formation.
The results showed that the combination treatment of BBR and DDP induced apoptosis and cell cycle arrest in the G0/G1 phase.
Molecules  •  2021  |  View Paper
Besides, it was aimed to investigate whether berberine could enhance the anti-cancer effect of 5-fluorouracil and cisplatin in HEP2.
Moreover, a down regulation of these genes caused by cisplatin or 5-fluorouracil, treatment of election in laryngeal cancers was enhanced by a 4h pre-treatment with berberine.
Journal of biological regulators and homeostatic agents  •  2018  |  View Paper
Importantly, BBR restrained the expression of cellular PCNA, and immunofluoresence analysis of γH2AX showed that BBR increased the DNA damages induced by cisplatin.
MTT assay showed that BBR inhibited breast cancer MCF-7 cell growth with a 50% inhibitory concentration (IC50) value of 52.178±1.593 … 49.541±1.618 µM, while in combination with 26 µM BBR, the IC50 value of cisplatin was 5.759±0.76 µM. BBR … cisplatin ….
Oncology reports  •  2016  |  View Paper
Therefore, we conclude that BER treatment reduces cisplatin resistance of gastric cancer cells by modulating the miR-203/Bcl-w apoptotic axis.
We found that BER treatment significantly reversed cisplatin sensitivity and induced caspase-dependent apoptosis in SGC-7901/DDP and BGC-823/DDP cells; BER treatment induced miR-203 expression, and overexpression of miR-203 mimicked the cisplatin-sensitizing effect of BER.
In Vitro Cellular & Developmental Biology - Animal  •  2016  |  View Paper
CONCLUSIONS Be berine ca n obviously increase the antitumor effect of cis platin by enhancing the function of the gap junction possibly in A549 cells.
The cisplatin-induced inhibition of colony growth was enhanced when berberine was combined with cisplatin.
Zhongguo fei ai za zhi = Chinese journal of lung cancer  •  2015  |  View Paper
Berberine could synergistically enhance the cell killing effect of other antitumor agents such as cisplatin.
When combined with cisplatin, Berberine showed a strong synergistic anticancer effect against ovarian cancer cells.
Anti-cancer agents in medicinal chemistry  •  2015  |  View Paper
Berberine enhanced cisplatin induced apoptosis and induced G0/G1 cell cycle arrest in A2780 cells.
Conclusion: The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells.
Results: In this study, we found A2780/DDP cells that were incubated with berberine combined with cisplatin had a significantly lower survival than the control group.
Cellular Physiology and Biochemistry  •  2015  |  View Paper
In this study, we investigated whether berberine could modulate the sensitivity of ovarian cancer cells to cisplatin and explored the mechanism.
The cisplatin-resistant SKOV3 cells that were incubated with berberine combined with cisplatin had a significantly lower survival than the cisplatin alone group and enhanced cisplatin-induced apoptosis.
The results suggested that berberine could modulate the sensitivity of cisplatin via regulating miR-21/PDCD4 axis in the ovarian cancer cells.
Acta biochimica et biophysica Sinica  •  2013  |  View Paper
Notably, berberine treatment significantly inhibited cell growth and colony formation in the two cell lines, berberine in combination with cisplatin exerting synergistic growth inhibitory effects.
Asian Pacific journal of cancer prevention : APJCP  •  2013  |  View Paper
We report that the sensitivity of resistant cells to cisplatin or to BESpm is reverted to the levels of sensitive cells by the co-treatment with berberine.
International journal of oncology  •  2013  |  View Paper
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