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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Additionally, berberine produced a parallel rightward shift of the concentration‐response curve of carbachol in a competitive manner with a pA2 of 3.87 ± 0.045.”
Relaxant action mechanism of berberine identified as the active principle of Argemone ochroleuca Sweet in guinea‐pig tracheal smooth muscle“ Berberine , applied to the basolateral bathing solution, also reduced SCC responses to the following agents which stimulate chloride secretion in rat colon: carbachol , forskolin, sodium nitroprusside, dibutyryl cyclic‐AMP, heat‐stable E. coli enterotoxin, 8‐bromo‐cyclic GMP and thapsigargin.”
“Conversely, prevention of the mobilization of store Ca+2 in the phasic contraction phase induced by carbachol and prevention of the calcium entry from extracellular in first phase elicited by high levels of potassium play only a minor role in the dilatory effect of berberine.”
“In addition, the carbachol induced phasic contraction in Ca+2 -free solution was only inhibited at the highest concentration of berberine.”
“These results suggest that the major mechanism of berberine consists of an inhibition of calcium entry from extracellular in the second phase induced by both carbachol and KCl.”
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