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Last Updated: 3 years ago

Possible Interaction: Berberine and Bleomycin

supplement:

Berberine

Research Papers that Mention the Interaction

Cumulatively, through targeted inhibition of dysregulated Smad and FAK-dependent PI3K/Akt-mTOR signaling axis, berberine attenuated the fibrotic insults of bleomycin.
Journal of Molecular Medicine  •  2015  |  View Paper
Berberine administration significantly ameliorated the bleomycin mediated histological alterations and reduced the inflammatory cell infiltrate in BALF.
Berberine inhibited the bleomycin mediated activation of inflammatory mediator nuclear factor kappa B (NF-κB) and suppressed its downstream target inducible nitric oxide synthase (iNOS).
The immunological sign of bleomycin stimulated mast cell deposition and histamine release were considerably reduced by berberine.
Toxicology letters  •  2013  |  View Paper