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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Beractant
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Pharmacological manipulation revealed that beractant activates a Ca2+ signal through Ca2+ release from intracellular stores mediated by phospholipase Cβ (PLCβ), Ca2+ release from inositol 1,4,5-trisphosphate receptors (IP3Rs) and Ca2+ influx via a store-operated pathway.”
“… beractant , at a concentration of 500 μg/ml, which has been … an apoptotic effect in human fibroblasts, elicited different patterns of Ca2+ signals in NHLF: a) a single Ca2+ spike which could be followed by b) …) a sustained Ca2+ plateau or d) a sustained plateau overlapped by Ca2+ oscillations.”
Lung Beractant Increases Free Cytosolic Levels of Ca2+ in Human Lung Fibroblasts“ Calcium (5 mM) greatly reduced the viscosity of both Survanta and Infasurf at 37 degrees C. Studies on synthetic mixtures indicated that phospholipid/apoprotein interactions were important in the rheology of lung-derived surfactants and that palmitic acid and tripalmitin contributed to the increased viscosity of Survanta.”
Bulk shear viscosities of endogenous and exogenous lung surfactants.
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