Possible Interaction: Bepridil and Calcium Supplement

“ Bepridil blocked the suppressive effect of pre-administration of Ca (100 mg/kg).”

“ Bepridil is a drug that binds to troponin and increases calcium sensitivity of muscle contraction.”

“Furthermore, blockade of the Na+–Ca2+ exchanger with bepridil modestly reduced the calcium influx after injury.”

“Ryanodine, TMB-8, lidoflazine and bepridil , applied at the EC50, displaced the concentration-response curves for calcium and monensin to the right but reduced the maximal increase of the left ventricular pressure.”

“In the presence of bepridil , a net influx of calcium was revealed across the zona pellucida, which was reflected by an increase in the [Ca2+]i.”

“Inhibition of Na+‐Ca2+ exchange with bepridil (50 µM) reduced significantly the Ca content of anoxic axons although mitochondrial Ca remained at anoxic levels.”

“We found that calcium entry is both necessary and sufficient to induce axonal degeneration after axotomy, and may be inhibited by cobalt, manganese, dihydropyridines, and bepridil.”

“2) … or bepridil , both known to …, increase the Ca++ sensitivity of the contractile structures of the heart, in high concentrations, as expected from the high natural abundance of troponin …) DPI 201-106 interacts with calmodulin (and presumably with the structurally closely related troponin C) in the microM concentration range.”

“Apparently, an additional calcium antagonistic effect also plays a role for flunarizine, lidoflazine, and for bepridil and, to a lesser degree, for verapamil and diltiazem.”

“At low frequencies (0.1 Hz) and negative holding potentials (-50 mV for Ca currents and -100 mV for Na currents), bepridil produced a concentration-dependent decrease in both Ca and Na currents without any significant change in the current-voltage relations.”

“The results indicate that bepridil , by inhibiting both Ca and Na currents, may have clinical usefulness in the treatment of certain ischemia-induced ventricular arrhythmias.”