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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Benzyl Isothiocyanate
supplement:
Phenethyl Isothiocyanate
Research Papers that Mention the Interaction
“PEITC or BITC plus PEITC significantly reduced levels of HPB releasing DNA adducts of NNK in lung at 8 and 16 weeks, but there was no effect of BITC.”
“These results demonstrate that dietary PEITC, or a mixture of BITC plus PEITC , inhibit the formation of HPB releasing adducts of NNK in the rodent lung, leading to inhibition of tumorigenesis.”
“… BITC … PEITC significantly inhibited the formation of Hb adducts of NNK from 2-12 weeks of treatment while there were no effects on Hb adducts of … a significant increase in levels of NNAL and NNAL-Gluc in the urine of the rats treated with PEITC or BITC plus PEITC.”
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.“Mixtures of PEITC and BITC (12 micromol of each, or 12 micromol PEITC and 9 micromol BITC) significantly reduced lung tumorigenesis induced by a mixture of BaP and NNK.”
“ PEITC , and PEITC plus BITC , both significantly inhibited lung tumor multiplicity; inhibition was due mainly to PEITC.”
“As a result, apigenin, benzylisothiocyanate , curcumin, diallyl disulfide,N-(4-hydroxyphenyl)retinamide (4-HPR), menadione, miconazole, nordihydroguaiaretic acid (NDGA) and phenethyl isothiocyanate showed potent inhibitory effects in this process.”
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