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Last Updated: 5 months ago

Possible Interaction: Benztropine and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Analogs of benztropine (BZT) that, like cocaine, act at the DAT have effects that differ from cocaine and in some situations block the behavioral, neurochemical, and reinforcing actions of cocaine.
Advances in pharmacology  •  2009  |  View Paper
Previous studies of benztropine analogues have found them to inhibit dopamine uptake like cocaine , but with less effectiveness than cocaine in producing behavioral effects related to drug abuse.
Pharmacology Biochemistry and Behavior  •  2007  |  View Paper
Two atypical inhibitors of the dopamine transporter, benztropine , used in the treatment of Parkinson's disease, and bupropion, used as an antidepressant, show very different psychostimulant effects when compared with another inhibitor, cocaine.
Journal of neurochemistry  •  2006  |  View Paper
Cocaine inhibited the transport of dopamine competitively with its structural analogues, cocaethylene and benztropine.
Journal of neurochemistry  •  1994  |  View Paper
Experiment 2 revealed that tranylcrypromine (2.5 mg/kg; s=1.7), fentanyl (0.068 …=1.34), morphine (>10 mg/kg), phencyclidine (0.81 mg/kg; s=1.43), and benztropine (9.2 mg/… stimulus generalization with cocaine , whereas lidocaine, procaine, chlordiazepoxide, imipramine, desipramine, …, isopropamide, and atropine do not.
Pharmacology Biochemistry and Behavior  •  1979  |  View Paper