supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Benztropine
supplement:
Cocaine
Research Papers that Mention the Interaction
“Analogs of benztropine (BZT) that, like cocaine, act at the DAT have effects that differ from cocaine and in some situations block the behavioral, neurochemical, and reinforcing actions of cocaine.”
Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.“Two atypical inhibitors of the dopamine transporter, benztropine , used in the treatment of Parkinson's disease, and bupropion, used as an antidepressant, show very different psychostimulant effects when compared with another inhibitor, cocaine.”
Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters“ Cocaine inhibited the transport of dopamine competitively with its structural analogues, cocaethylene and benztropine.”
“Experiment 2 revealed that tranylcrypromine (2.5 mg/kg; s=1.7), fentanyl (0.068 …=1.34), morphine (>10 mg/kg), phencyclidine (0.81 mg/kg; s=1.43), and benztropine (9.2 mg/… stimulus generalization with cocaine , whereas lidocaine, procaine, chlordiazepoxide, imipramine, desipramine, …, isopropamide, and atropine do not.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback