Possible Interaction: Benzoyl Peroxide and Cuprous

“ BzPO induced piperidine-labile sites at the 5'-site guanine of GG and GGG sequences of double-stranded DNA in the presence of Cu(I) , whereas the damage occurred at single guanine residues of single-stranded DNA.”

“Consequently, it is concluded that … by the reaction of BzPO … Cu(I) may oxidize the 5'-guanine of GG and GGG sequences in double-stranded DNA to lead to 8-oxodG … piperidine-labile guanine lesions, and the damage seems to be relevant to the tumor-promoting activity of BzPO.”

“Because free radical intermediates are produced by the reaction of BzPO with Cu(I) , we sought to determine whether BzPO plus Cu(I) caused DNA base damage typical of that caused by the hydroxyl radical.”

“The mouse skin tumor promoter benzoyl peroxide BzPO ), in conjunction with Cu(I) , causes promutagenic damage in DNA.”

“These data suggest that the reaction of BzPO with Cu(I) generates hydroxyl radical or a similarly reactive intermediate which causes DNA base damage.”

“ BzPO reacts with Cu(I) to produce the benzoyloxyl radical, which in turn causes strand breaks in plasmid DNA.”

“These data suggest that BzPO may interact with Cu(I) bound to G-C base pairs in DNA to produce site-specific promutagenic DNA damage.”