Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Benzocaine and Glutathione



Research Papers that Mention the Interaction

Furthermore, the addition of glutathione reduced ethyl ester (GSH-OEt), recovered intracellular GSH level, and cell viability with reduced the intracellular ROS level.
Archives of pharmacal research  •  2019  |  View Paper
Equally important, the antioxidants N-acetyl cysteine and GSH ethyl ester could significantly attenuate the EMT signaling stimulated by decreased GSH levels.
The American journal of pathology  •  2017  |  View Paper
Pretreatment with glutathione reduced ethyl ester (2 mM) not only reversed the changes in oxidative stress indicators and signaling molecules but also diminished RFP-induced reduction in green fluorescence intensity of MRP2.
Acta Pharmacologica Sinica  •  2019  |  View Paper
Monocytes exposed to glutathione reduced form ethyl ester (GSH‐OEt) or maleic acid diethyl ester (DEM) increased or decreased the intracellular GSH/GSSG ratio, respectively.
Journal of leukocyte biology  •  2002  |  View Paper
The … GSH ethyl ester almost completely prevented the increase in GCS-HS mRNA and decreased H2O2levels and that transient transfection with catalase (but not manganese-superoxide dismutase) … GCS-HS mRNA only in CYP2E1-expressing cells suggest a possible role for H2O2 in the induction of GCS-HS gene transcription.
The Journal of Biological Chemistry  •  2000  |  View Paper
GSHee enhanced cell proliferation and GSH concentration without affecting protein synthesis but inhibited proteolysis.
Amino Acids  •  2015  |  View Paper
These findings show that the ethyl ester of GSH but not GSH per se can elevate intracellular GSH , that brain elevation of GSH requires central delivery of the ethyl ester and that this elevation provides neuroprotection against oxidative stress or chronic mitochondrial impairment.
Experimental Neurology  •  2007  |  View Paper
Importantly, GSH ethyl ester reduced the toxic effects of KA, becoming significant at 1 mM (P=0.007 vs. KA-treated group), and was maximal at >/=2.5 mM (P<0.0001).
Brain Research  •  2000  |  View Paper
Pretreatment of both mouse and rat stromal cells with GSH ethyl ester also provided a dramatic protection against HQ-induced toxicity.
Journal of toxicology and environmental health  •  1995  |  View Paper
The finding that administration of BSO ethyl ester led to about a 25% decrease in the brain level of glutathione within 15 min suggests that a fraction of brain glutathione turns over very rapidly and may therefore be of special physiological significance.
Brain Research  •  1990  |  View Paper