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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Benzocaine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Furthermore, the addition of glutathione reduced ethyl ester (GSH-OEt), recovered intracellular GSH level, and cell viability with reduced the intracellular ROS level.”
Synergistic effect of buthionine sulfoximine on the chlorin e6-based photodynamic treatment of cancer cells.“Equally important, the antioxidants N-acetyl cysteine and GSH ethyl ester could significantly attenuate the EMT signaling stimulated by decreased GSH levels.”
“Pretreatment with glutathione reduced ethyl ester (2 mM) not only reversed the changes in oxidative stress indicators and signaling molecules but also diminished RFP-induced reduction in green fluorescence intensity of MRP2.”
“Monocytes exposed to glutathione reduced form ethyl ester (GSH‐OEt) or maleic acid diethyl ester (DEM) increased or decreased the intracellular GSH/GSSG ratio, respectively.”
“The … GSH ethyl ester almost completely prevented the increase in GCS-HS mRNA and decreased H2O2levels and that transient transfection with catalase (but not manganese-superoxide dismutase) … GCS-HS mRNA only in CYP2E1-expressing cells suggest a possible role for H2O2 in the induction of GCS-HS gene transcription.”
“ GSHee enhanced cell proliferation and GSH concentration without affecting protein synthesis but inhibited proteolysis.”
N-acetylcysteine stimulates protein synthesis in enterocytes independently of glutathione synthesis“These findings show that the ethyl ester of GSH but not GSH per se can elevate intracellular GSH , that brain elevation of GSH requires central delivery of the ethyl ester and that this elevation provides neuroprotection against oxidative stress or chronic mitochondrial impairment.”
“Importantly, GSH ethyl ester reduced the toxic effects of KA, becoming significant at 1 mM (P=0.007 vs. KA-treated group), and was maximal at >/=2.5 mM (P<0.0001).”
“Pretreatment of both mouse and rat stromal cells with GSH ethyl ester also provided a dramatic protection against HQ-induced toxicity.”
“The finding that administration of BSO ethyl ester led to about a 25% decrease in the brain level of glutathione within 15 min suggests that a fraction of brain glutathione turns over very rapidly and may therefore be of special physiological significance.”
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