“Androgens in males and DHEA overdose might reduce the efficacy of BCG.”
“However, the addition of high dose (0.1%) DHEA decreased the efficacy of high dose (2 × 105 CFUs) BCG in suppressing the airway responsiveness and eosinophilia.”
“In conclusion, the combination of low doses of BCG and DHEA had an additive effect in suppressing the development of airway hypersensitivity.”
“In female mice, the combined … of 2 × 104 CFUs BCG and ….01% DHEA effectively suppressed the ovalbumin-induced increase in airway sensitivity to methacholine (56.5 vs. 8.2 mg/mL, p < 0.01), while BCG (13.9 mg/mL) or DHEA (17.9 mg/mL) alone did not.”