Possible Interaction: Barium and Potassium

“ Barium is a potent, non-specific inhibitor of the potassium IRC current and affects all types of muscle at micromolar concentrations.”

“ Barium acts by redistribution of potassium from the extra- to intravascular compartment causing hypokalemia.”

“The effect of barium (Ba2+) treatment, which inhibits potassium currents by blocking potassium channels, on retinal development was examined.”

“Application of amiloride alone to the haemolymph space had no effect on the intracellular potassium concentration … (between the basal region of basal membrane infoldings and the apical brush border), whereas a potassium increase as well as a chloride increase was … the potassium conductance of the basal membrane with barium.”

“At low but not at high extracellular potassium concentrations the potassium conductance can be blocked by barium.”

“The basolateral membrane conductance may be a potassium conductance that is blockable by barium.”

“We also found that intracellular barium was an effective blocker of the potassium currents.”

“Thirty μM barium (Ba2+) and 10 μM ouabain partially blocked potassium‐induced , but had no effect on acetylcholine‐induced vasorelaxation in saphenous arteries.”

“The potassium current was blocked by tetraethylammonium, 4-aminopyridine, barium and cobalt.”

“Expression of two of these channels in Xenopus oocytes gave rise to inwardly rectifying potassium currents which were voltage-dependently blocked by barium and cesium.”